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Product Review: MD Skincare Dr. Dennis Gross Alpha Beta Daily Face Peel

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The peel is also available in a 60-day supply for $125.00.  Photo courtesy Amazon.com.

MD Skincare: Dr. Dennis Gross Alpha Beta Daily Face Peel ($75.00 for a thirty-day supply, Sephora.com) claims to “improve skin firmness, tone, and texture, Alpha Beta diminishes the appearance of fine lines and wrinkles, boosts skin density and vitality, and reduce pore size and breakouts.”  To find out why this product is so effective, and my personal evaluation after use, read on.

A high concentration of salicyclic acid in Step 1

Salicylic acid is an oil-soluble chemical exfoliant that can remove debris from the pore, creating the appearance of skin smoothness. However, according to Dr. Diana Draelos, an associate professor of dermatology at Wake Forest School of Medicine, it cannot measurably reduce pore size, only cleanse the area. Still, according to Mount Kisco, New York dermatologist David E. Bank, M.D.: “The goal is to keep pores clean and at their smallest,” so salicyclic acid is excellent to use to clean the pores. However, salicyclic acid does not actually change pore size; rather, it cleans the pores, which enables them to then be closed after cell turnover is increased, etc.

Glycolic acid in Step 1

Although the concentration of glycolic acid is not provided on the MD Skincare: Dr. Dennis Gross Alpha Beta Daily Face Peel, glycolic acid is typically available in at-home treatments in 8 to 15 percent concentrations.  (In dermatologist’s offices, glycolic acid peels are available in concentrations up to 70 percent.)   Still, glycolic acid in at-home treatments has still been found to advance desquamation and thinning of the stratum corneum (the uppermost layer of the skin). By exfoliating the top layer of the skin, glycolic acid peels smooth the skin, quicken the rate of cell turnover (which is reduced by up to 7% every ten years), decrease small wrinkles and increase the fibroblast proliferation of collagen.

At these low concentrations, Dr. Leslie Baumann, Director of Cosmetic Dermatology at the University of Miami School of Medicine, notes that the patient should not expect reversal of moderate to severe wrinkling or scarring with at-home treatments. In fact, according to a randomized, placebo-controlled double-blind study, it was found that 0.05% all-trans-retinoic acid (a retinoid) was more effective than 2% lipoic acid or 10% glycolic acid (a concentration found in at-home treatments) in treating signs of aging.

Green tea in steps 1 and 2

Green tea has been found to be effective as a potent antioxidant and anti-inflammatory ingredient in skin care formulations.  In addition, green tea has promise as a treatment against rosacea.  According to Dr. Gary Goldfaden, M.D., “In a recent dermatological comparison study, the use of a lotion containing a tea extract produced a 70% improvement in rosacea compared to use of a lotion containing the base ingredients alone. This tea extract is rich in antioxidant polyphenols and contains a variety of potent flavonoids.” Verifying this is a 2003 study in the Journal of Nutritional Biochemistry, which reports that green tea reduces UVB-induced inflammation as measured by double-fold skin swelling. This is also a great ingredient in MD Skincare: Dr. Dennis Gross Alpha Beta Daily Face Peel because it will help reduce some of the inflammation caused by a potent salicyclic acid/glycolic acid peel combination.

Vitamin C and Vitamin E in Step 2

Vitamin C is most commonly used as L-ascorbic acid in skin care formulations.  However, MD Skincare: Dr. Dennis Gross Alpha Beta Daily Face Peel contains vitamin C as ascorbyl palmitate, a more stable form of vitamin C that is slightly less researched and used than L-ascorbic acid in skin care formulations.  According to a 1987 article in the journal Cancer Research, ascorbyl palmitate was more effective in preventing tumor formation in the mouse than other forms of vitamin C, including L-ascorbic acid.  Ascorbyl palmitate has also been established as being an effective antioxidiant in microemulsions, according to this study in the European Journal of Pharmaceutics and Biopharmaceutics, amongst others.

The combination of vitamin C and vitamin E have been found to synergistically enhance the power of one another, and have been reported by Djerassi et. al. to prevent the formation of carcinogenic nitrosamines (although in different forms of C and E). Vitamin C and vitamin E have also been shown in this 1996 study, amongst others, to enhance the photoprotective effects of sunscreen, which is most likely why the product is recommended for morning use.

Soy isoflavones and retinol in Step 2

MD Skincare: Dr. Dennis Gross Alpha Beta Daily Face Peel contains soy isoflavones, which are effective anti-aging ingredients.  One isoflavone contained in soy is genistein, which has been shown in independent research studies to exhibit both anti-inflammatory and antioxidant properties, and to stimulate the production of collagen and hyaluronic acid in human fibroblasts cultured in vitro, which together increase the firmness, elasticity, and suppleness of skin. These findings have been affirmed in this 2005 study in the journal of Photochemistry and Photobiology, which further reported that use of soy extract twice daily for two weeks reduced the number of hair follicles (dermal papillae) on the skin. Finally, it has been reported in this 2000 study in the journal Dermatology that human trials demonstrate lightening of hyperpigmentation after use of soybean extract for two weeks.

Retinol has been demonstrated to increase cell turnover, reduce the appearance of fine lines and wrinkles, smooth the skin, and reduce acne in some patients.  However, retinol use is also associated with skin irritation in some patients with sensitive skin, and use of retinol makes your skin more susceptible to sun damage.  Because the sun is a major cause of signs of aging, be sure to use this product with daily application of a broad-spectrum UVA/UVB sunscreen.

Soothing and hydrating ingredients in Steps 1 and 2

Step 1 contains a high concentration of soothing chamomile extract, along with anti-inflammatory green tea extract and hydrating lactic acid.  Step 2 contains a high concentration of hydrating dimethicone and anti-inflammatory green tea extract, and a low concentration of soothing chamomile.  Because glycolic acid peels can be harsh to the skin, the plethora of soothing and anti-inflammatory ingredients make this peel a great one.

Personal Use

After trying MD Skincare: Dr. Dennis Gross Alpha Beta Daily Face Peel, I noticed that my skin immediately felt smoother and slightly firmer.  I also noticed that my first application made my skin flake off somewhat, so I wouldn’t recommend using the product for the first time right before a big event (the flakiness makes it harder to apply make-up).  Hours later, my skin had a slight sheen to it, and it feels smoother.

The product is fragrance-free, which is always a bonus.   Although it is recommended for day use, I can’t bring myself to use a peel at night (I am too paranoid about sun damage for that).

A 60-day supply is also available at Sephora for $125.00, so it’s like buy one, get one 33% off if you go this route.  Quite expensive, so if you are already using anti-aging antioxidants and are just looking for an effective peel, the Peter Thomas Roth UnWrinkle Peel Pads ($45.00, Amazon.com) might be a better fit for you.  While Peter Thomas Roth UnWrinkle Peel Pads do not contain soy isoflavones and have less green tea, they contain seemingly more glycolic acid.  Check out the review here.

As a result…

A great product!   I love it, although if $75.00 for 30 days is too much for you to spend on a peel, you may want to consider Peter Thomas Roth UnWrinkle Peel Pads for $45.00 for 60 days, without soy isoflavones and less green tea, but seemingly more glycolic acid.  One caveat:  Watch out if you have sensitive skin, and talk to your dermatologist if you have concerns before you try this or any other product with AHAs and/or retinol.

Step 1 Ingredients:

Salicylic Acid, Chamomilla Recutita Matricaria Extract, Citric Acid, Copper PCA, Disodium EDTA, Fragrance, Glycolic Acid, Camellia Sinensis Extract, Lactic Acid, Malic Acid, Polysorbate-20, Water, Alcohol Denat., Sodium Benzoate, Soy Isoflavones, Genestein, Hamamelis Virginiana, Achillea Millefolium Extract, Zinc PCA.

Step 2 Ingredients:

Water, Dimethicone, Camellia Sinensis Extract, Ascorbyl Palmitate, Cholecalciferol, Tocopheryl Acetate, Phospholipids, Soy Isoflavones, Genestein, Retinol, Copper PCA, Zinc PCA, Chamomilla Recutita Matricaria Extract, Achillea Millefolium Extract, Methylparaben, Phenoxyethanol, Potassium Hydroxide, Diazolidinyl Urea, Tetrasodium EDTA.

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February 25th, 2008 Posted by futurederm | Antioxidant Treatments, Best Products, Best Products, Best Skincare Gifts, Firming Treatments, Product Reviews | 2 comments

Advice from Dermatologist Dr. David McDaniel

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Oh, Happy Day! That’s what I said when the March 2008 issue of Allure arrived, complete with a feature on one of my all-time favorite dermatologists, Dr. David McDaniel. Dr. McDaniel is Board Certified by the American Board of Dermatology and is an Assistant Professor of Clinical Dermatology and Plastic Surgery at Eastern Virginia Medical School,. and Director of The Institute of Anti-Aging Research. He is a favorite dermatologist of mine due to the great amounts of research he conducts on cosmeceuticals and subsequently publishes in peer-reviewed scientific research journals. Here is an excerpt from the Allure article:

Dr. McDaniel’s To-Do-List for Great Skin

  • Don’t smoke, and wear sunscreen.
  • Watch out for fat. “There’s a growing understanding that both body fat and dietary fat are connected with inflammation…And there are some good studies suggesting a low-fat diet reduces the incidence of pre-cancerous skin lesions and also alters the skin’s response to UV damage.”
  • Avoid or neutralize free radicals. Free radicals are caused by UV rays (both from the sun and tanning beds), pollution, cigarette smoke, pesticides, and other sources. McDaniel is a big believer in the power of berries, tomatoes, and other fruits and vegetables: “Each plant is a little chemical factory, and since we need to be defended against all the forms of free radicals, there is value in eating a variety.” Makes sense - eating and topically applying antioxidants has been found to be more effective than either method alone (full article here).
  • Use products for 4-6 weeks before judging a product. “People think they can get results in three or four days. Ideally, I’d like patients to try skin products for six to eight weeks before they judge, but I know that doesn’t fly…so I tell the four to six weeks and hope they do four.” Dr. Kenneth Beer, a dermatologist in Palm Beach, agrees: “The complete benefit of skin creams won’t be visible until after a full cycle of skin-cell turnover to take place, at least a month.”

Dr. McDaniel’s Current Assessment of Skin Care Products

“The potency, the delivery systems, and the science have improved. But there are still a lot of products that are more invested in marketing and packaging than science.” (I, for one, couldn’t agree more.)

What Dr. McDaniel Sees for the Future of Skin Care

“In the next couple of years, we’ll see things like sound and radio waves that work on tissues under the skin and selectively destroy cellulite or elevate the eyebrows without a brow lift.” Exciting stuff indeed…

Five Anti-Aging Products Recommended By Dr. McDaniel

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  • Prevage MD. (shown above) “A superpotent antioxidant that contains idebenone.” According to Allure, McDaniel’s clinical trials have shown that idebenone use produces 38% improvement in the appearance of fine lines and wrinkles.
  • Retin-A Micro. (A personal favorite of mine, too!) “Retin-A is one of the great anti-aging products; this is reformulated for improved delivery and strength.” Available by prescription only, but a proven great investment for the future of your skin.
  • Priori Radical Defense SPF 30. “A great new concept, with sunscreen and the antioxidant Idebenone combined in one bottle.” Relatively hard to find, it is available from eBay for $74.99 plus shipping and handling.
  • Skinceuticals CE Ferulic. (A personal favorite of mine, too!) “Another great antioxidant combination using stabilized vitamin C, which plays a key role in the formation of new collagen fibers. It tested really well for preventing sun damage.” (I used Skinceuticals CE Ferulic under sunscreen every morning for four years, and I swear by it. Only recently did I switch to Cellbone Technology C15ie Advanced Serum, for the addition of 5% idebenone and $35 less, but unfortunately also 5% less vitamin E. A full review of Cellbone Technology C15ie Advanced Serum will be on the site in about a month!)
  • RevaléSkin. (A personal favorite of mine, too!) “It features CoffeeBerry, which has one of the highest and most potent mixtures of antioxidants.”

You have to love interviews with research dermatologists! :-) I will try to recruit dermatologists for my own interviews in the future.

If you or someone you know is a research dermatologist who would like to be interviewed on the site (currently receiving over 1800 page views/day), please feel free to contact me at Nicki [at] FutureDerm [dot] com.

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February 25th, 2008 Posted by futurederm | Interviews | 7 comments