Comments on: Product Review: Wexler MMPi 20 Skin Brightening and Pore Refining Serum & Daily Defense Anti-Oxidant Tinted Moisturizer SPF 30

By: Ian

Ian — Mon, 17 Aug 2009 02:11:53 +0000

Well I can say now my search is over for the greatest blog that gives information on this topic, this is the best!

By: Maria G.

Maria G. — Thu, 09 Jul 2009 18:58:55 +0000

Tara – let us know if you try Regeneration Booster and how you like it. Sarah – thanks for the article – good information on that site too.

By: Dave

Dave — Sat, 04 Jul 2009 19:01:39 +0000

New wexler serum contains denatured alcohol? if it does, in which part of ingredient list? thanks

By: Sarah

Sarah — Fri, 03 Jul 2009 20:44:41 +0000

also here’s a really cool study on niacinamide you guys should look at

http://www.ncbi.nlm.nih.gov/pubmed/16939485

By: Sarah

Sarah — Fri, 03 Jul 2009 20:38:45 +0000

here’s an answer from a dermatologist i asked: http://users.erols.com/gtodorov/skincare/aha_bha.htm

“The dangers of excessive skin exfoliation:
Less wrinkles today could mean more wrinkles tomorrow”

hey nicki I have a really random question…should you use retinoids/antiaging products on your nose/ears or are they cartilage and not age the same way.

By: Tara

Tara — Sat, 27 Jun 2009 17:48:54 +0000

I too am very interested in the issue Sarah and Maria raised. I’ve been trying to research it as well but have not come up with anything as of yet. Jan Marini makes a product called Regeneration Booster. It is supposed to preserve the length of skin telomeres using something called telomerase which is along the same line of what I think SIRTUINS are supposed to do. I’d love to try this product but need a little more info (its costly). I’m also wondering if just like Sirtuin products like AVON ANEW it’s not a good idea to use it with niacinamides? Any thoughts on this subjects or products of this type in the future would be greatly appreciated!

By: futurederm

futurederm — Fri, 26 Jun 2009 22:24:20 +0000

Hi Maria,

That’s an excellent point that you and Sarah both raise, and I have had the same thought myself. Unfortunately I haven’t read any studies comparing the potential or actual effects of sirtuins and retinoids over time. Of course, there is also the possibility that both could work – sirtuins could turn off only the unnecessary gene expression in cells, preserving valuable cellular energy, while retinoids could increase the rate of cell turnover of the cells with limited/selective gene expression. Of course, this may very well not be the case; I honestly don’t know and cannot find the answer.

I will, however, keep you posted on any advances in this area.

Keep the great questions/insights coming!
Best,
Nicki

By: Maria G.

Maria G. — Fri, 26 Jun 2009 21:20:20 +0000

Hi Nicki – Sorry to bring up an old subject but Sarah had a good comment back on June 1 – & maybe there’s no answer to this question right now. But if Sirtuins keep the cells living longer and retinoids/ahas make the cells turn over faster and thus die faster — then which of these is the true anti-ager? Is it possible they could work together?…one of them for short-term gain and the other to preserve the cells longterm? It’s very confusing and the way they work seems to contradict one another–
thanks for your thoughts!

By: Stephanie

Stephanie — Mon, 22 Jun 2009 05:02:38 +0000

If you add up your tally for the Moisturizer, it equals 10 not 9. I think you have a typo.