Comments on: Can a Skin Care Cream Really Alter Your Skin’s DNA?

By: Ruben

Ruben — Thu, 17 Dec 2009 00:08:22 +0000

According to my professor biochemistry the future of skincare is in DNA repair and one of the top ingredients to do so far is folic acid(part of the VIT B group). And althoug skincare is lawed as epidermis level, everything is but true. Most skincare products these days work on the junction which therefore has the ability to penetrate to the dermis.

By: futurederm

futurederm — Wed, 16 Dec 2009 05:39:33 +0000

Hi Judith,

Thanks for the link, as well as for the theory. I was thinking that the ideas were contradictory because typically the lifespan of a cell correlates to its reproductive lifespan; thus, if retinoids cause increased cell turnover, it is theoretical that the fibroblasts will have a shorter lifespan overall. However, perhaps the cell life cycles of the old and new generations simply overlap more, rather than the older generation dying, in which case you are right, and there are more fibroblasts! Fascinating.

I may talk to some experts who conduct research in anti-aging for an interview…you’ve inspired me.

Thanks Judith!
Best,
Nicki

By: judith

judith — Wed, 16 Dec 2009 05:33:30 +0000

I am not sure that prolonging fibroblast lifespan and increasing the rate of division of fibroblasts are contradictory. The net result of either is more fibroblasts.

Also recently it has been shown that SIRT1 (sirtuin 1) plays a role in regulating circadian rhythms, so the effect of resveratrol may be on clock genes.

e.g http://www.ncbi.nlm.nih.gov/pubmed/19286518

It amazing how we are realizing how little we know. I think it is an exciting time for aging research.