Do Vitamin C and Sodium Benzoate Together Form a Carcinogen?

Submitted via the FutureDerm.com Facebook page:

Do vitamin C and sodium benzoate form a carcinogen?  I read that somewhere, but I wanted to ask you if it was true.

-T

Dear T,

Without careful examination, this looks like a story worthy of the front page of The New York Times!  Vitamin C and sodium benzoate (a preservative) will together form benzene, which has been associated with causing cancer (International Journal of Occupational and Environmental Health, 2007).  For the ultra-scientific, benzene is associated with causing DNA strand breaks, and high levels of exposure have been associated with acute myeloid leukemia (AML), aplastic anemia, myelodysplastic syndrome (MDS), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML).(Annual Review of Public Health, 2010).

However, most beauty products contain sodium benzoate in extremely low concentrations – parts per billion or less.

Still, considering the fact that soft drinks also contain very low amounts of benzoates, and 2.5% of 200 soft drinks with vitamin C and sodium benzoate were found to have levels of benzene above allowable levels (FDA, 2007), there is still the moot possibility that some skin care and cosmetics could contain benzene.  So here is what to do:

How to Protect Yourself

High amounts of vitamin C + a high pH (above 3) = significantly reduced benzene production!

Chemical reactions are a lot like meeting a potential partner:  The conditions matter.  Just like dim lighting, a fancy restaurant, and a dozen roses can flip that nerd from accounting from the “friend zone”, so can quantities of chemicals, temperature, and the pH make a world of difference with a chemical reaction.

Such is the case with vitamin C and sodium benzoate.

Benzene does not form at all if you use beauty products with a very high concentration of vitamin C and a low concentration of sodium benzoate (AIB International, 2006).   Why?  Increasing amounts of vitamin C cause for it to act as a free radical scavenger rather than in the sodium benzoate reaction.  (Look at it this way:  Your date offers to take you to a restaurant you despise, and you would have a bad reaction.  But if he offers to take you to the Academy Awards instead, you have a better option, and you’d do that instead.)

Products formulated with a pH of 3 or above are also safer than those with a pH of 2 or less (AIB International, 2006).  And above a pH of 7, no benzene forms at all.  This is unfortunate, because it leaves vitamin C formulations a very narrow window of pH 3.0 to 3.5 to work with, as vitamin C has been shown to work best at a pH of 3.5 or lower (Dermatologic Surgery, 2008).

So you won’t catch me using vitamin C products in non-acidic form, even if they don’t form benzene with benzoates/benzoic acid.  Instead, I simply use concentrated vitamin C products, and I avoid sodium benzoate and benzoic acid together with vitamin C.

Bottom Line

Protect yourself and still maintain efficacy of vitamin C by using products with: a.) high vitamin C; b.) no benzoic acid or benzoates; c.) storing your beauty products in a cool, dark place.

In short, using a product with high concentrations of vitamin C should eliminate the vast majority of benzene formation. Other options include using parabens (which are safe in skin care and cosmetics) instead of preservative systems like sodium benzoate and benzoic acid, both of which form benzene with vitamin C; and keeping your beauty products in a cool, dark place, as higher temperatures and light incite the reaction to benzene (AIB International, 2006).

But let me get on my soapbox for just a minute – this is what the problem is with society’s general distrust of skin care and cosmetics ingredients nowadays.  Databases are automatically flagging studies about parabens.  And despite the fact that I have never spoken to a dermatologist or cosmetic scientist who does not approve parabens for anyone who is non-allergic, the non-scientifically-trained public is demanding products without parabens.  As a result, some manufacturers are using benzoic acid and benzoates instead – and guess what.  They’re an actual problem!  At least, they are when combined with vitamin C. *sigh*

So, for now, avoid products with benzoic acid and benzoates, especially when using vitamin C.

Related Posts

  • FutureDerm, Home made vitamin c toners; normally including vitamin c crystals or powder in a solvent such as tea or distilled water that you use for a week and discard. Trick or treat? Is this receipe worth a go? -Noella My Dear Readers (And Noella), Imagine walking into a Michelin three-star restaurant run by a…
  • In recent years, there has been a turn in the beauty and cosmetics industry against parabens.  The reason?  Some studies show high concentrations of parabens can weakly mimic estrogens (Toxicology and Applied Pharmacology, 2008; The Journal of Steroid Biochemistry and Molecular Biology, 2002).  Other studies have shown parabens accumulate in human breast tissue (Journal of…
  • As longtime readers of the FutureDerm blog know, we love vitamin C here. Loooove it.  But we’re particularly excited today because our Vitamin CE Caffeic Serum is almost here, and for the next week (until March 31) you can pre-order yours! Vitamin C is known for doing all kinds of wonderful things for your skin…

by Nicki Zevola

4 thoughts on “Do Vitamin C and Sodium Benzoate Together Form a Carcinogen?

  1. Nicki Zevola says:

    Hi @Aprill!

    Substitutes for parabens include:
    *Organic acids, like benzoic acid, or benzoates, or benzethonium chloride
    *Sodium hydroxymethylglycinate (HMG)
    *Hydantoins
    *Certain alcohols, like phenoxyethanol (common)
    *Diazolidinyl urea
    *Combinations of acids and alcohols

    Quite frankly, I hope that this whole issue resolves itself with parabens. No manufacturer uses them above 0.25% now, so I don’t understand why there is this much of a controversy still lingering. They are only shown to be harmful in extremely high doses, and they are eliminated from the body in 36 hours. Introducing these alternative preservative systems is not helping and is actually furthering suspicion of the beauty industry/ingredients.

  2. RJ says:

    Regarding preservatives, all I keep hearing is how they’re all bad, so I do appreciate your post. Have you read studies that showed parabens being found in breast cancer masses in women? This is what made me stray away at first, but I understand that can be from packaged food. I’d like to know though what preservatives are safe for you? I know you mentioned above that phenoxyethanol is a sub for parabens, but “The product’s Material Safety Data Sheet (MSDS) says that it phenoxyethanol is harmful if swallowed, inhaled or absorbed through the skin and that it can cause reproductive damage.” Some studies show it being unsafe in even small doses. So one day it’s Sodium Benzoate and the next it’s something else. It’s getting harder to make educated decisions regarding skin care now.

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>