To a small extent, Biotulin Supreme Skin Gel has been promising similar results, claiming on Amazon, “Less wrinkles and a visibly younger look within 60 minutes? With the new biotulin no sorcery. Developed in the US and produced in Germany, this extract is comparable to needle injections containing Botulinum Toxin. The results are similar!”
Without going into a full ingredient analysis, I’ll just say, I’m not that impressed with Biotulin Supreme Skin Gel. The premise is supposed to be that Spilanthol is a local anesthetic extracted from the plant Acmella oleracea (paracress). There is a patent for the use of Spilanthol for a “wrinkle-freezing” effect like Botox, but the patent includes the use of other “freeze” peptides like acetyl hexapeptide 8, which Biotulin Supreme Skin Gel does not include.
The other issue with Spilanthol is that I cannot find in vivo (as in, on living humans) tests or trials with the ingredient. In vitro — as in, in petri dishes- – a 0.6% concentration by volume of the extract blocks muscle contractions rapidly; and a 1.2% concentration sustains it over a 24 hour period. In vitro, the magnitude of the effectiveness is also cited in the patent to be dose dependent. A 2% concentration showed a consistent wrinkle smoothing effect in vivo after 24 hours and this continued to increase over the next 28 days.
However, judging from the ingredients list of Biotulin Supreme Skin Gel, I am skeptical that the product contains a full 0.6-1.2% concentration, mainly because its location on the ingredients list makes me guess there is 1-2% Acmella Oleracea extract, and of that, far less Spilanthol.
So, look, here’s the bottom line: At FutureDerm, I look for three things in skincare — ingredients that are proven to work, in vivo, in peer-reviewed scientific research; ingredients are in concentrations in which they are proven to work; and solid delivery systems. Here, we have butylene glycol and alcohol, which will help deliver ingredients deeper into the skin, but I’m skeptical of Spilanthol, particularly when added as Acmella Oleracea extract rather than 0.6-1.2% actual Spilanthol, and I’m also skeptical that it works without the use of other “freeze” peptides. So I’m going to give this one a hard pass and “no thanks” for now.
Ingredients in Biotulin Supreme Skin Gel: Aqua/Water, Glycerin, Butylene Glycol, Alcohol, Imperata Cylindrica root extract, Acmella Oleracea extract, Xanthan gum, Carrageenan, Benzoic acid, Phenoxy-ethanol, Vitis Vinifera (Grape) leaf extract, Sodium Hyaluronate, Sodium Hydroxide, Carbomer, Caprylyl Glycol, Acrylates / C10-30 Alkyl-acrylate coss-polymer, Ethylhexyl-Glycerin, Dehydro-acetic acid, Sodium Bisulfite.