Easydew EX Repair Control Renewal Moisture is a moisturizer designed to improve wrinkles and to fade acne scars. The secret here is two-fold: First, 2% niacinamide may help to improve skin tone and discoloration and aid in hydration, whereas 0.02 ppm epidermal growth factor (EGF) may help to promote new skin cell growth and multiplication.
How Growth Factors Work
In essence, growth factors are naturally occurring proteins in the body that may signal and simulate skin repair, regeneration, and the production of the collagen and elastin that makes your skin soft and supple. Over time, natural levels of growth factors in our bodies decline. Supplementing skin with growth factors may help return skin to its optimal health.
When applied topically, growth factors are most commonly used to treat conditions such as fine lines and wrinkles, discoloration/sunspots, and lost elasticity. Some critics have brought up the point that most of your human growth factors are larger than 15,000 Daltons in terms of molecular weight, which makes it very difficult for them to penetrate deeply within the stratum corneum.
While I would usually consider this to be a deal breaker (after all, what’s the point of applying something that just rests on the skin?), Dr. Gregory Nikolaidis points out that growth factors do not need to penetrate the skin deeply in order to be effective. In fact, Dr. Nikolaidis notes that “Growth factors and cytokines create a signaling pathway from the superficial cells to deeper ones, with keratinocytes in the upper dermis affecting a response from the fibroblasts in the dermis. The stratum corneum is simply a loose layer of dead skin cells overlying live keratinocytes underneath” (Aesthetic Medicine).
For those of you who want to bypass the scientific jargon, here’s the gist in plain English: growth factors (and cytokines) can more or less pass over the dead skin cells that form the stratum corneum and create a signaling pathway with the living skin cells deeper with the skin. Therefore, despite being rather large, growth factors are still able to meaningfully impact and improve cellular functioning.
What Can Growth Factors Do for My Skin?
Quite a bit, actually. While growth factors all broadly aim to improve the appearance of damaged and aged skin, each growth factor has its own specialized function and abilities. For example, hepatocyte growth factor (HGF) is believed to promote formation of the extracellular matrix and encourage three dimensional tissue growth, whereas interleukins-10,-13, and -15 are believed to promote wound healing and soothe inflammation (Facial Plastic Surgery).
A number of growth factors have also been linked with speedy wound healing. For example, topically-applied nerve growth factor (NGF) was found to promote granulation tissue formation, reepithelization, and collagen production in wounded skin. Research published in Biomedical Research International noted that this exceptional wound healing may have been due in part to NGF’s ability to encourage fibroblast migration. Basic fibroblast growth factor (bFGF) has similarly been linked to improved wound healing by means of promoting fibroblast migration and proliferation (Research in Experimental Medicine (Berlin).
Several clinical studies have also suggested that growth factors can encourage collagen synthesis and improve the appearance of fine lines and wrinkles (Dermatologic Therapy, The Journal of Clinical and Aesthetic Dermatology). For example, research published in the Journal of Cosmetic Dermatology suggested that epidermal growth factor (EGF) and fibroblast growth factor (FGF1) both encouraged the regeneration and proliferation of skin cells, indicating that they may be suitable topical agents for those who wish to reverse signs of aging. In a 2006 study published in the journal Dermatologic Surgery, experimental participants applied either a vitamin C-containing serum or a growth factor-containing serum. The growth factor-containing serum, which included transforming growth factor-beta(1) (TGF-beta(1)), hepatocyte growth factor (HGF), and platelet-derived growth factor subunit A (PDGF-A), notably improved the appearance of facial wrinkles.
Additionally, in a study from Suneva Medical, Inc. that evaluated skin improvement when applying a skin care product formulated with growth factors, statistically significant improvements in investigator assessments of tactile roughness, visual texture, wrinkles, blotchiness, skin tone evenness, radiance and translucency compared to baseline were observed (2).
This Sounds Great and All – But Do I Really Need to Use Growth Factors?
Well, this depends. There are already a great number of anti-aging ingredients on the market which can cater to several different budgets. As far as ingredients go, growth factors are still relatively new, unregulated, and found in only a handful of brands’ products at the moment. But does that mean that you should pass them up for your tried and true ingredients?
No! Of the select few ingredients that have truly fascinated me and gained my respect in recent years, growth factors are certainly one of them. Although they may not be as popular as something like a retinoid or vitamin C, growth factors are still worth your attention. Better yet, as they gain more traction with skincare aficionados, growth factor-containing products are likely to become more affordable and prevalent.
If nothing else, consider this. Growth factors are found naturally within the skin, and are responsible for facilitating intercellular communication and regulating cell health. Yet as we age, our bodies produce lower levels of growth factors, which in turn can lead to decreased collagen and elastin production and overall diminished cellular functioning (Dr. Joel Schlessinger.com). So to repair fine lines, wrinkles, elasticity, sun spots, and several other signs of age-related damage, why not apply more of the very same hormones (growth factors) that are responsible for maintaining your skin’s appearance?
By incorporating a skin care product formulated with next generation growth factor technology and applying a rejuvenating blend of physiologically balanced growth factors to the skin, the natural proteins in your body may enhance the skin’s natural repair and renewal and help reverse the sings of aging. Essentially, skin cells have been conditioned to act like younger cells resulting in younger, fresher growth factors.
It’s also important to keep in mind that other ingredients can seldom match the dramatic results of using growth factors. Additionally, growth factor-containing products are seldom as pricey as undergoing surgery and rarely induce irritation, unlike many other popular anti-aging staples.
One of my employees expressed interest in using Easydew EX Repair Control Renewal Moisture for a four-week period on her acne scars. Here are her results:
When it comes to wrinkles and acne scarring, I think the best course of action for flat scars and wrinkles is microdermabrasion, followed by chemical peels with glycolic and/or lactic acids. On the other hand, if you have raised scars, I think that retinoids and anti-inflammatory compounds work particularly well.
However, if you have done all of the above and still have acne scars, Easydew EX Repair Control Renewal Moisture can be a nice addition to your skincare regimen, and couldn’t do anything but help. Again, however, I recommend Easydew EX Repair Control Renewal Moisture only if you’ve tried AHAs, retinoids, and microdermabrasion first.
How To Use:
After cleansing, toning and using treatment products, dispense the cream into the palm of the hand. Smooth or pat over skin, until fully absorbed. Apply additional layer on areas with fine lines and wrinkles. Follow with SPF during the day or use it as your last skin care step at night.
Active ingredients: Niacinamide 2.0%, Adenosine 0.04%, Nepidermin 0.0002% (2ppm)
Water, Glycerin, Cetyl Ethylhexanoate, Caprylic/Capric Triglyceride, Dicaprylyl Carbonate, Pentylene Glycol, Cetearyl Alcohol, Glyceryl Stearate, Dimethicone, Polysorbate 60, 1,2-Hexanediol, Caprylic/Capric/Myristic/Stearic Triglyceride, Stearic Acid, PEG-100 Stearate, DI-C12-13 Alkyl Malate, Sorbitan Sesquioleate, Caprylyl Glycol, Hydroxyethyl Acrylate/Sodium AcryloyldimethylTaurate Copolymer, Polyacrylamide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C13-14 Isoparaffin, Fragrance (Parfum), Tromethamine, Alcohol Denat., Xanthan Gum, Disodium EDTA, Laureth-7, Hydrogenated Lecithin, Phytosphingosine, Saccharide Isomerate, BHT, Potassium Cetyl Phosphate, Helianthus Annuus (Sunflower) Seed Oil, Sodium Ascorbyl Phosphate, Centella Asiatica Extract, Citric Acid, Sodium Citrate