Brimonidine

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An alpha-2 andrenergic antagonist that

Brimonidine (Wikipedia)
Brimonidine
Brimonidine structure.png
Systematic (IUPAC) name
5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxalin-6-amine
Clinical data
Trade names Alphagan, Mirvaso
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a601232
Pregnancy
category
  • US: B (No risk in non-human studies)
Routes of
administration
Ocular (eye drops), topical (gel)
Legal status
Legal status
Pharmacokinetic data
Metabolism Primarily liver
Biological half-life 3 hours ocular 12 hours topical
Identifiers
CAS Number 59803-98-4 YesY
ATC code D11AX21 (WHO) S01EA05
PubChem CID 2435
IUPHAR/BPS 520
DrugBank DB00484 YesY
ChemSpider 2341 YesY
UNII E6GNX3HHTE YesY
KEGG D07540 YesY
ChEBI CHEBI:3175 YesY
ChEMBL CHEMBL844 YesY
Chemical data
Formula C11H10BrN5
Molar mass 292.135 g/mol
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Brimonidine (bri-MOE-ni-deen) is a drug used as eye drops under the brand names Alphagan and Alphagan-P to treat open-angle glaucoma or ocular hypertension, and as a gel, Mirvaso, for facial skin redness in rosacea.

It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye through uveoscleral outflow; brimonidine treats reddened skin (erythema) by causing narrowing of blood vessels (vasoconstriction).

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