Perricone MD Chia Seed Serum Review

Reviews, Skin Care
Perricone MD Chia Seed Serum

Perricone MD Chia Serum ($75.00, contains less coenyzme Q10 than DHC Quick Gel Brightening Moisture, but I still like it for dry to very dry skin types, with its ample amounts of omega-3 fatty acids embedded in chia oil. Perricone MD Chia Serum requires only a drop or two for application for most people, and it takes a minute or so to absorb. It has a strong, almost off-putting scent, but if you are the type of person who regularly uses natural or organic scented products, you may be used to this type of scent. Its main benefit is hydration.

To incorporate Perricone MD Chia Serum into a skin care routine, I recommend using it after a vitamin CE serum, like our FutureDerm Vitamin CE Caffeic Serum. This is because vitamins C and E work in the same pathway as coenzyme Q10, strengthening the antioxidant action even further. While retinol can make skin sensitive to the sun, its retinyl palmitate is quite weak, so I would not worry about it thinning the skin, especially when used with a vitamin CE serum and under a broad-spectrum UVA/UVB sunscreen with an SPF of at least 30.

Coenzyme Q-10: Antioxidant and Anti-inflammatory Action

Coenzyme Q-10 — also known as ubiquinone — is found naturally in the human body as something essential for the production of cells (Mayo Clinic). Coenzyme Q-10 levels are at their highest for the first 20 years of life and then subsequently decrease as we age. Researchers are investigating how this antioxidant might be related to the aging process and longer life span. Though it’s shown process with lab rats, it doesn’t appear to do much for lab rats (MedlinePlus).

Coenzyme Q-10 is considered a regenerative antioxidant (Journal of the American College of Nutrition). When applied to the skin, Coenzyme Q-10 has been shown to penetrate the skin layers and reduce the oxidation, reduce wrinkles, and prevent UVA-irradiation damage (Biofactors). It’s antioxidant and coenzyme effects also help prevent cell death.

Q-10 is an integral part of the mitochondrial electron transport chain, which is depolarized by UVB-irradiation. When skin was treated with Q-10 before UVB exposure, it mitigated these effects and increased cell viability (Journal of Biological Chemistry).
In addition to this, Coenzyme Q-10 helps to suppress the inflammation that occurs with UV-irradiation. That was magnified when coenzyme Q-10 was applied with carotenoids like beta-carotene  (Journal of Cosmetic Dermatology). When mixed with carotenoids, it’s also able to stop the UVR induction of matrix metalloproteinase-1, which degrade collagen (Journal of Cosmetic Dermatology). In this way it serves as a powerful ingredient in anti-aging.

Coenzyme Q-10 can degrade in heat and light, so products in air tight, opaque containers are ideal (Chemical Pharmacy Bulliten).

Coenzyme Q10 Works Together with Vitamin C and Vitamin E

As longtime FutureDerm readers know, different antioxidants work on different pathways within the skin. There are at least three major pathways that detoxify the skin (as well as the rest of your cells) from free radicals (Nature, 2013). 

What makes coenzyme Q10 great for use with vitamin C as L-ascorbic acid and vitamin E is that it operates in the same pathway as these antioxidants. This means that, when any of the three antioxidants encounter a free radical and neutralize it, losing an electron in the process, they can be regenerated by having one of the other two antioxidants donate an electron (Cosmetic Dermatology). For this reason, coenzyme Q10-containing products are a great addition to use with vitamin C + vitamin E-containing products, like our FutureDerm Vitamin CE Caffeic Serum

Chia Seed: Is There Any Known Benefit for the Skin?

Chia seed is a natural source of omega-3 fatty acids (Poultry Science, 2002), which are anti-inflammatory fatty acids naturally found within the skin. Omega-3 fatty acids are documented to be substantially lower in those with dry/very dry skin types than those with normal to oily skin types, though omega-3 supplementation (whether oral or topical) can help this, returning skin to a more youthful, supple state.

Topical chia seed oil has also been documented in the journal Annals of Dermatology to relieve severe symptoms of pruritus, or skin itching.

Overall, is chia seed oil going to remove your fine lines and wrinkles? Fix hyperpigmentation? Encourage collagen production? Answer: Probably not; no; almost certainly no. But, if you suffer from dry to very dry skin, chia seed oil is likely to temporarily plump up your skin, reducing the appearance of fine lines somewhat.


water/aqua/eau, butylene glycol, glycerin, ascorbyl glycoside, olea europaea (olive) fruit oil, pentylene glycol, squalane, hydrogenated lecithin, potassium hydroxide, carbomer, betaine, phenoxyethanol, acrylates/C10-30 alkyl acrylate crosspolymer, cetearyl alcohol, glyceryl stearate SE, tocopherol, ubiquinone, glycosyl trehalose, hydrogenated starch hydrolysate, stearyl glycyrrhetinate, polyglyceryl-10 myristate, cetearyl glucoside, glycine soja (soybean) sterols, bellis perennis (daisy) flower extract, sodium hyaluronate, placental protein, soluble collagen, olea europaea (olive) leaf extract, morus alba root extract, sodium riboflavin phosphate, cyanocobalamin

Bottom Line

Coenzyme Q-10 has beneficial effects in and on the body and hasn’t been found to have many negative reactions, though it is as of yet untested on pregnant women and children. Some think it could help people live longer because it’s in every cell and is an integral part of cell production. On skin, it’s a powerful antioxidant and excellent for anti-aging, and works particularly well in conjunction with vitamin C as L-ascorbic acid and vitamin E.

What are your thoughts on Coenzyme Q10? Let’s discuss in Comments below!

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