Skinceuticals Triple Lipid Restore 2:4:2 Review

Reviews, Skin Care







Skinceuticals Triple Lipid Restore 2:4:2 is the latest innovation from Skinceuticals. Your skin naturally contains lipids like triglycerides, fatty acids, squalane, wax esters, and cholesterol. These lipids are an important part of your skin’s ability to retain moisture and to keep bacteria out that can lead to inflammation, breakouts, and infection (Cosmetic Dermatology).

But as you age, your skin naturally produces fewer and fewer lipids. And the lipids your skin does produce lack integrity, meaning they may not have the same structure, be able to function as well, or be able to perform at the same level they did when you were young.

FutureDerm Skin Diagram

The biggest example of the importance of lipids in the skin is seen in a skin does order called X-linked Ichthyosis, which leads to abnormally dry, hard, resistant skin. This disorder is caused by defects in lipid metabolism. Deficiencies in lipids even in individuals without X-linked Ichthyosis have been known to predispose people to exceptionally dry skin — for instance, it’s well-established that a decrease in lipid production contributes to the rough, tight, full and dry skin associated with aging.


So I am really excited about this new product. While I have seen plenty of moisturizers with fatty acids OR ceramides OR cholesterol, I haven’t seen one yet with all of those elements, and certainly not at 2% ceramide, 4% cholesterol, and 2% fatty acid concentration.

What the Studies Show

It has been shown in Skinceuticals’ own in-house studies that use of Skinceuticals Triple Lipid Restore 2:4:2 will help to refill skin stores of essential skin lipids, restore the skin’s external barrier, and support skin’s natural repair.

In fact, in-house Skinceuticals studies have shown a 57% increase in ceramides, a 50% increase in cholesterol, and a 12% increase in fatty acids after regular use for 8 weeks. Better yet, there was a 30% immediate improvement in barrier recovery and 39% improvement in hydration after 24 hours!Skinceuticals Triple Lipid Restore 2:4:2

I checked the studies, and they had everything I’m looking for: large enough sample size (28), ingredients were used in the same/reasonable concentrations, and it was tested using spectrometric analysis — not personal reporting methods!

Personal Use and Opinions

So right now, I’m using my usual skin care, plus Murad Rapid Age Spot and Pigment Lightening Serum to fade some sunspots I newly acquired on a beach vacation last week (despite, of course, vigilant sunscreen use!). The only issue with upping glycolic acid and hydroquinone is that it has been making my skin feel more dry and thin initially — so using Skinceuticals Triple Lipid Restore 2:4:2 has been a godsend. I use it immediately after a retinoid and the Murad Rapid Age Spot and Pigment Lightening Serum nightly, and it is keeping my skin hydrated, soft, and comfortable, despite the fact that I’m accelerating cell turnover and turning off tyrosinase like nobody’s business!

Bottom Line

I’m very impressed by Skinceuticals Triple Lipid Restore 2:4:2, especially for skin over 50 that is losing its natural production of natural intact lipids, as well as for younger skin that is being treated regularly with stronger agents like glycolic acid, retinoids, hydroquinone, salicylic acid, and other ingredients that can be harsh and drying initially to the skin. LOVE it! 10/10.

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  • Vendela

    It seems this product is based on silicones with a ton of proven irritants like menthol, lavender oil, isobutane, fragrance, etc. Not to mention the jar packaging will likely make any antioxidant value evaporate upon use..

    Also the Murad product has a ton of denatured alcohol- the bad kind of alcohol and multiple irritants and fragrance. I’m sure you could find a better formulated hydriquinone product without those harsh ingredients. I understand some types of alcohol are ok to help the product penetrate but denat is never good. I understand if this is a sponsored post.

  • tracey

    I have recently been researching moisturizers with retinol as I am 49 with plenty of wrinkles, six year Hx of what I was told is cystic acne for which I finally gave into taking an antibiotic in the lowest dose possible for and am 5 months in with some decrease in acne action–however the damage I have done in those six years is UGLY. To make a long story short in my desperation and that is exactly what it is Desperation–i ordered some thing I saw on face book of all places–that had retinol in it and it has made some positive changes–so I started researching in this big confusing arena of skin care products–I read your 11 things to know about retinol and loved the answers and explanations you gave–so understandable and like the sarcastic humor at times as well. So here is what I am looking for–is it possible to get some information on what products in your line I can use to change the damage to my skin–which is oily with fairly large pores scattered about–better with the retinol product–wrinkles from sun and smoking damage and still stuff surfacing from the questionable dx of cystic acne–then would it be possible to get some samples of these products to try as we all know anyone in my shoes has spent countless number of dollars on skin care products that don’t work—I am in desperate mode here folks–I have spent six years of my life hiding because of my face–I would like to live again and be comfortable with my skin–Please provide my some help and guidance–I would like to stop the antibiotics–hate taking them and just have smooth clear skin–thank you for your time and anticipated answer–Tracey J Schippani 241 Woodtick rd Wolcott Ct 06716

  • Good review, Nicki! Like you, I’m using Triple Lipid Restore and love it!

  • Grace

    I don’t see the full list of ingredients. It’s helpful because perhaps one can find a similar product at a reasonable price. How many of these $50-$100 products can people afford?

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