Tretinoin, Retinol, and Retinyl Palmitate: The Key to Anti-Aging Success?

Skin Care
FutureDerm Time-Release Retinol 0.5

According to Dr. David E. Bank, director of the Center for Dermatology, Cosmetic & Laser Surgery, researchers discovered the anti-aging properties of Retin-A, a prescription topical treatment containing a derivative of vitamin A, in 1985, when it was first used as an acne treatment. Patients reported decrease in the appearance of wrinkles and smoother skin, in addition to a reduction in acne.

The active ingredient in Retin-A, tretinoin (brand name Renova), is the only chemical to date to receive FDA approval for anti-aging and anti-sun damage properties. According to research by Fisher et. al cited by Dr. Leslie Baumann in Cosmetic Dermatology, retinoids are effective in preventing and treating the collagen loss caused by photodamage. UV exposure decreases collagen types I and III with 24 hours, but treatment of the skin with all-trans retinoic acid prevents the loss of these types of collagen synthesis. In addition, Fisher et. al demonstrated that application of tretinoin inhibits the induction of matrix metalloproteinase genes (more here), which are in part responsible for collagen degradation.

Side effects of retinol include skin irritation, desquamation, and redness. In addition, use of vitamin A derivatives has been associated with birth defects, and so it is advisable for women who are pregnant, breast-feeding, or those who may become pregnant to avoid use of tretinoin, retinol, or retinyl palmitate. It is further notable that patients with sensitive skin should use lower concentrations of tretinoin (0.025% rather than 0.1%) or, alternatively, lower concentrations of different metabolites of vitamin A, namely retinol or retinyl palmitate. According to Dr. Baumann, retinol and retinyl palmitate should be present in concentrations of at least 0.04% to 0.07% and packaged properly (to avoid oxidation) in order to be effective, as they are in Neutrogena Healthy Skin with SPF 15 ($23.78,, ROC Retinol Correxion Instant Facial Smoother, and FutureDerm Time-Release Retinol 0.5, of course! 🙂

ROC Retinol Correxion Instant Facial Smoother

So how are retinol and retinyl palmitate related to the proven-effective tretinoin? According to Dr. Baumann, retinol is classified as a cosmetic rather than a drug because it must first be converted to retinaldehyde, and then all-trans retinoic acid within the skin in order to be effective. In general, retinol is considered to be about 20 times less potent than retinoic acid, and thus higher concentrations of retinol need to be used to achieve similar efficacy to all-trans retinoic acid (i.e., 0.04% or 0.07% versus 0.025%). However, although retinol needs to be present in higher quantities than tretinoin in order to be effective, patients typically experience lower levels of irritation using retinol products. Similarly, retinyl palmitate is a combination of pure retinol and palmitic acid (a substance typically used in cosmetics as a cleansing agent), and so it too must be converted to retinaldehyde and then all-trans retinoic acid within the skin in order to be effective. However, when present in sufficiently high concentrations, retinyl palmitate displays results similar to that of retinol. One caveat: based on information from Dr. Baumann’s site, make-up products with retinol will expire approximately one month after opening, so use accordingly.

FutureDerm Tretinoin Products Prescription

Tretinoin itself is available in five prescription formulas: Retin-A Micro (Johnson & Johnson), Renova (Johnson & Johnson), AvitaDifferin (Galderma), and Tazorac (Allergan). According to Dr. BankRetin-A Micro uses microsphere technology to allow a more sustained release of tretinoin over time. Some patients may find Retin-A Micro drying, in which case Renova, a product with tretinoin delivered in a mineral-oil base, may be recommended. A third option, Avita, is considered to be less irritating than Retin-A Micro, but without the mineral-oil base that can stimulate acne in some patients. The fourth option, Differin, contains a different chemical, adapalene, and is considered to make skin less photo-sensitive than other tretinoin products. Lastly, the newest product, Tazorac, contains tazarotene, and may be drying, but was approved by the FDA in 1997 for the treatment of acne. According to Dr. Baumann, a 2000 study by Kakita et. al found that the efficacy of tazarotene 0.1% gel is clinically comparable to 0.1% tretinoin [in Retin-A Micro] and 0.025% gel tretinoin[Renova] and adapalene 0.1% gel [Differin].

Vitamin-A derivatives are thereby considered to be excellent prevention and treatment against the signs of aging caused by ultraviolet rays. However, the effects of vitamin A derivatives on sensitive skin can be harsh. As such, provided one is not breast-feeding, pregnant, or may become pregnant, s/he should talk to their dermatologist about making the right choice of tretinoin, retinol, or retinyl palmitate for a part of their anti-aging routine on a daily basis.


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  • As a doctor, I’m often asked about over the counter skincare products for anti-aging and reducing wrinkles and fine lines. Many times clients are basing their purchases strictly by marketing materials or opinions. It’s refreshing to find a website such as yours that’s dispensing researched reviews that combine science and personal experience. Well done and keep up the great work Nicki!

  • Bebe

    Hi Nicki! I’m not using prescription strength retinoids at the moment but am considering it and was browsing online chemists just to look at the kinds of retinoids available. On one particular website for Retin-A there were the usual warnings to not use if pregnant, trying to get pregnant, breast feeding, eczema, etc but there was also a warning to not use retin A if you have ulcerative colitis, which I have. I’ve heard of accutane being linked to ulcerative colitis but do you think topically applied retinoids, prescription strength or not, could exacerbate ulcerative colitis symptoms?

  • Nicki Zevola

    @Maria — Both retinol and glycolic acid increase cell turnover. It is true that this increased exfoliation may temporarily make your skin more sensitive to the sun, especially before the compounds have the time to increase collagen production within your skin, which takes weeks to months. Retinol and glycolic acid both also break down in the presence of UV light.

    I recommend using retinol or glycolic acid at night. I like antioxidant serums under sunscreens during the day.

  • Nicki Zevola

    @Jan – Atralin is the same as Retin-A.

  • Nicki Zevola

    Hi @TKnCK — Both products are good. Verso Super Facial Serum claims to be eight times more effective than other typical forms of retinol, but that is really a clever way of saying that it is (most likely) either microencapsulated or packaged in liposomes. StriVectin is also a good retinol product, as it has a vitamin B3 complex that helps with skin yellowing as well.

    Hope this helps!

    • TKnCK

      Nicki thank you for your thoughts. I trade off with StriVectin when Verso is to expensive. My DR. said he could give me an rx that was just as strong for less money but my skin would break out from. Didn’t know that B3 helps prevent yellowing, as always thank you for the information.

  • Maria

    Is it a good idea to use anything at all with a retinol product during the day or for that matter any AHA? I’ve always avoided doing that; seems to be counter-effective.

  • Jan

    What about Atralin? I find it to be totally non irritating even on my sensitive skin.

  • TKnCK

    Hi Nicki. What are your thoughts of the Verso Super Facial Serum with Retinol 8 and their newest product dark spot remover, over priced or deserving of the hype ? Any thoughts on StriVectin – AR ? At 60 is it a waste of time to be using the products or is their still hope of improving skin quality ? My skin still breaks out, lucky me.

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